Pharmacy

Van Minh Le, Ph.D.

Senior Researcher, Pharmacotechnology and Biopharmacy Laboratory NTT Institute of Hi-Technology, Nguyen Tat Thanh University Email: lvminh@ntt.edu.vn Tel: +84-8-62717296

Research Focus

Traditional medicine researchs: Extracting and screening natural compounds from plant with anticacer activity or supportive roles during cancer treatment; conducting research on traditional medicine, herbs that have pharmaceutical properties against some chronic diseases (cancer, diabetes, high blood pressure).

      

Tumor biological and cancer therapeutic researchs: Researching on cancer cells biology, pharmacology, pharmacokinetic on molecular, cellular and/or animal models.

Nanopharmacology and toxicology studies: Researching and applying nanotechnology in diagnosis and treatment: developing stealth drug-delivery systems, improving physical properties and/or efficacy of drugs…

Education

B.S. , Biotechnology, East China University of Science and Technology, 2011

Ph.D., Pharmacy,  East China University of Science and Technology, 2015

Publications

Conference:

1. Van Minh Le, Nho Trung Duc Tran, Long Giang Bach and Jian Wen Liu. Evaluation anticancer of folate modified 5-florouracil-loaded nanoparticles. The 5th International workshop on nanotechnology and application (IWNA 2015). 2015, Vung Tau, Viet Nam.
2. Le Van Minh, Liu Jian Wen*. A folate conjugated drug loaded micelle to reverse multidrug resistance in colorectal cancer. Asia – Pacific organization for cancer prevention regional conference. 2014, 61-62.  Ha Noi, Viet Nam.

Journals:

[1] Trần Nho Trung Đức, Bạch Long Giang, Nguyễn Hoàng Dũng, Phùng Thị Thu Hương, Lê Văn Minh*. Tiềm năng và ứng dụng liposome trong chuẩn đoán và trị bệnh. Tạp chí Dược học. 2016, 479, 6-9.

[2] Nguyễn Hoàng Dũng, Lê Quỳnh Loan, Kim Eun-Ki, Lê Văn Minh, Đặng Trần Quân, Trần Thị Thanh Loan. Khảo sát hoạt tính làm trắng da của rau diếp cá (Houtiuynia cordata thumb.) trên dòng tế bào u hắc tố B16F10 ứng dụng trong mỹ phẩm. Y Học TP.Hồ Chí Minh, 2016, 20(2):19-24.

[3] Zheng Yuanhong, Yin Guifang, Le Vanminh, Zhang Anle, Chen Siyu, Liang Xin, Liu Jianwen. Photodynamic-therapy Activates Immune Response by disrupting Immunity Homeostasis of Tumor Cells, which Generates Vaccine for Cancer Therapy. Int J Biol Sci 2016; 12(1):120-132.

[4] Yuanhong Zheng, Fangyuan Zou, Jingjing Wang, Guifang Yin, Vanminh Le, Zhewei Fei and Jianwen Liu*. Photodynamic Therapy-mediated Cancer Vaccination Enhances Stem-like Phenotype and Immune Escape, Which Can Be Blocked by Thrombospondin-1 Signaling through CD47 Receptor Protein. British Journal of Pharmacology, 2015 : 290(14):8975-86.

[5] Yiyin Chen, Le Van Minh, Jianwen Liu, Borislav Angelov, Markus Drechsler, Vasil M. Garamus, Regine Willumeit-Römer, Aihua Zou.  Baicalin loaded in folate-PEG modified liposomes for enhanced stability and tumor targeting. Colloids and Surfaces B: Biointerfaces,  2015, 140, 74-82.

[6] Van Minh Le, Jing-Jing Wang, Ming Yuan, The-Long Nguyen, Gui-Fang Yin, Yuan-Hong Zheng, Wei-Bin Shi, Mei-Dong Lang, Lei-Ming Xu*, Jian-Wen Liu*. An investigation of antitumor efficiency of novel sustained and targeted 5-fluorouracil nanoparticles. European Journal of Medicinal Chemistry, 2015 , 92, 882–889

[7] Van Minh Le, Mei-Dong Lang, Wei-Bin Shi, Jian-Wen Liu*. A collagen-based multicellular tumor spheroid model for evaluation of the efficiency of nanoparticle drug delivery. Artificial Cells, Nanomedicine, and Biotechnology. 2014, 1–5.

[8] Weibin Shi, Vanminh Le*, Chunhua Gu, Yuanhong Zheng, Meidong Lang, Yanhua Lu, Jianwen Liu*. Overcoming multidrug mesistance in 2D and 3D multure models by controlled drug chitosan-graft poly(caprolactone)-based nanoparticles. Journal of Pharmaceutical Sciences 2014, 103, 1064-1074. (Co-first author)

[9] Chunhua Gu, Vanminh Le, Meidong Lang*, Jianwen Liu*. Preparation of polysaccharide derivates chitosan-graft-poly(ε-caprolactone) amphiphilic copolymer micelles for 5-Fluorouracil drug delivery. Colloids and Surfaces B: Biointerfaces 2014, 116 745-750.

[10] Ming Yuan, Yan Xiao*, Vanminh Le, Chao Wei, Yutong Fu, Jianwen Liu and Meidong Lang*. Micelle controlled release of 5-fluorouracil: follow the guideline for good polymer-drug compatibility. Colloids and Surfaces A Physicochem Eng Aspects 2014, 457, 116-124.

[11] Yinbo Chen, Vanminh Le, Xiaoyong Xu, Xusheng Shao, Jianwen Liu, Zhong Li*. Discovery of novel 1,5-benzodiazepine-2,4-dione derivatives as potential anticancer agents. Bioorganic & Medicinal Chemistry Letters 24 (2014) 3948–3951.

[12] Anle Zhang, Yuanhong Zheng, Zujun Que, Lingling Zhang, Shengchao Lin, Vanminh Le, Jianwen Liu, Jianhui Tian. Astragaloside IV inhibits progression of lung cancer by mediating immune function of Tregs and CTLs by interfering with IDO. Journal of Cancer Research and Clinical Oncology, 2014, 140(11):1883-1890.

[13] Ke Shen, Rurong Mao, Li Ma, Yueqi Li, Yanyan Qiu, Daling Cui, Vanminh Le, Peihao Yin,*, Lei Ni, and Jianwen Liu. Post-transcriptional regulation of the tumor suppressor miR-139-5p and a network of miR-139-5p-mediated mRNA interactions in colorectal cancer. The FEBS Journal, 2014, 281(16): 3609–3624.

[14] Huang Ding, Li Wenming, Zhao Liang, Fan Li, Ye Zhaoyang, Liu Xuping, Tan Wensong, Luo Jian, Chen Ze. Optimization of chemically defined serum- and protein-free medium for MDCK cells by Plackett-Burman experiment design combined with response surface analysis. Chinese Journal of Biologicals, 2014, 27 (6): 835-842.

[15] Yuanhong Zheng,  Vanminh Le, Zhuoan Cheng,  Sheng Xie,  Hegeng Li,  Jianhui Tian,  Jianwen Liu. Development of rapid and highly sensitive HSPA1A promoter-driven luciferase reporter system for assessing oxidative stress associated with low-dose photodynamic therapy. Cell Stress and Chaperones (2013) 18:203–213.